Precision cancer prevention-interception refers to an approach employing cancer preventive-interceptive interventions individually tailored for different higher-risk populations such as those with hereditary cancer syndromes (HCS) and individuals diagnosed with high-grade precursor abnormalities that place individuals at higher risk of cancer e.g., precancer. In this FOA, cancer prevention means primary prevention of cancer before the oncogenic process begins, while cancer interception is defined as disruption of the oncogenic process during the precursor or precancer state or stage. The overall goal of this FOA and the CAP-IT Data and Resource Coordination Center (CAP-IT DRCC) is to establish an agile and effective network infrastructure to undertake collaborative research focusing on precision cancer prevention and interception, with the overarching goal of discovering molecularly or immunologically targeted agents designed to prevent or intercept the oncogenic process in specific higher-risk populations. The purpose of this Funding Opportunity Announcement (FOA) is to solicit Applications for Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) Centers (U54). The CAP-IT network will be formed by U54 Specialized Centers (this FOA) and one Data and Resource Coordination Center (CAP-IT DRCC). To discover innovative targeted agents through in vitro and in vivo efficacy evaluation and advance promising efficacious agents to the NCI's existing R&D pipeline for further development.To functionally validate the critical roles of the high-value oncotargets in tumor initiation and/or progression to invasive cancer and select oncotargets suitable for targeted intervention strategies and.High-value tumor-driving molecular targets/pathways, immune targets, and tumor-specific/tumor-associated antigens, collectively referred to as "oncotargets" in this FOA, will be prioritized for the discovery of targeted interventions To identify targets that can be potentially exploited for cancer preventive or interceptive interventions specifically in higher-risk populations, by collaborating with the NCI and other programs with a research focus on molecular profiling of established precursor/precancer, early cancer, and/or oncogenic signaling pathways.To achieve the Program's overarching goal, CAP-IT research objectives are: The overall goal of the CAP-IT Program is to establish an agile and effective network infrastructure to undertake collaborative research focusing on precision cancer prevention and interception, with the overarching goal of discovering molecularly or immunologically targeted agents designed to prevent or intercept the oncogenic process in higher-risk populations. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) Centers (U54).
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